MiniVent Ventilator for Mice (Model 845), Single Animal, Volume Controlled

MiniVent Ventilator for Mice (Model 845), Single Animal, Volume Controlled

The MiniVent Model 845 Ventilator is a quiet, compact and light weight ventilator. While it was designed specifically for mice, the MiniVent can be used for any animal (e.g. birds and perinatal rats) which requires tidal volumes in the range of 30 to 350 µl and respiratory rates of 60 to 400 breaths per minute.

  • Ideal ventilator for mice
  • Stroke volume range from 30 to 350 µl
  • Ventilation rate from 60 to 400 breaths/minute
  • Simple adjustment of stroke volume while running

Full Description

The MiniVent Model 845 Ventilator is a quiet, compact and light weight ventilator designed specifically for mice. It can be used for any animal (e.g. birds and perinatal rats) which requires tidal volumes in the range of 30 to 350 µl and respiratory rates of 60 to 400 breaths per minute.

Key Features

  • Ideal ventilator for mice
  • Stroke volume range from 30 to 350 µl
  • Ventilation rate from 60 to 400 breaths/minute
  • Simple adjustment of stroke volume while running
  • Valveless piston pump, no valves to clog
  • Very small instrument/circuit dead space volumne
  • Compact construction, easy to install close to animal
  • No vibrations, very low noise


How it Works

The MiniVent Ventilator is a constant-volume respiration pump operating on the Starling principle. Unlike conventional units for larger animals, this ventilator employs a rotary plunger and has no valves. During each ventilation cycle, the plunger performs a synchronized forward and rotating movement. Cleverly arranged bores and channels in the cylinder and plunger control inspiration and expiration during each stroke of the plunger.

The extremely light weight and compact construction, in addition to the convenient rod clamp, allow the MiniVent ventilator to be positioned directly next to the animal. Typical setups with larger ventilators produce large tubing and instrument dead space volumes. These larger volumes introduce greater system compliance which can affect the accuracy with which the full tidal volume is introduced into the animal’s lungs. With the MiniVent, the tidal volume error due to system compliance is reduced to ±3 µl.

Tidal volume and respiration rate can be set exactly to the values required for mouse ventilation. The level of precision and control available to the investigator minimizes the danger of hyperventilation or hypoventilation.

The tidal volume can be varied continuously from 30 to 350 µl during operation without having to interrupt ventilation. The respiration rate is also continuously adjustable from 60 to 400 strokes/min. The expired air can be recovered at the collection port for sampling, recycling or for the generation of a positive end-expiratory pressure (PEEP). Room air or any non-explosive gas mixture can be used to feed the pump intake.


Components

The MiniVent is supplied with 1 x AC Wall Mounted Power Supply (115 V or 220 V); 2 x Silicone Tubing (1.5mm ID, 3.0mm OD, 14cm long); 1 x 1.3mm OD Tracheotomy Cannula (73-2730); 1 x 1.2mm OD Intubation Cannula (73-2844).

A multi-gas inlet adapter is available for the MiniVent so that alternate gas mixtures and nebulized substances are delivered to the MiniVent inlet port at atmospheric pressure. The adapter provides ports for multiple selectable gas mixtures (hypoxic, anesthetic...) and a port for the Aerosol Nebulizer.

  • Valveless piston pump, no valves to clog
  • Very small instrument/circuit dead space volumne
  • Compact construction, easy to install close to animal
  • No vibrations, very low noise
Specifications73-004373-0044
AC Adapter Weight English0.70.7
AC Adapter Weight Metric0.30.3
CertificationsCECE
Control ModesVolumeVolume
Depth English7.97.9
Depth Metric2020
Displaynonenone
Gas SupplyRoom air or non-flammable mixed gasRoom air or non-flammable mixed gas
Height English3.13.1
Height Metric88
I:E Ratio1:11:1
ModelMiniVentMiniVent
Net Weight English2.22.2
Net Weight Metric11
Number of Animals11
PEEPProvided via attachment of water columnProvided via attachment of water column
Respiration Rate Maximum400400
Respiration Rate Minimum6060
Respiratory Rate NoteContinuously adjustable from 60 to 400 breaths/minContinuously adjustable from 60 to 400 breaths/min
Sigh Frequencynonenone
Sigh PressureNot availableNot available
SpeciesMice, Prenatal Rats, Small BirdsMice, Prenatal Rats, Small Birds
Stroke Volume NoteContinuously adjustable from 0.03 to 0.35 ml/strokeContinuously adjustable from 0.03 to 0.35 ml/stroke
Tital Volume Maximum0.13 ml/stroke0.35
Tital Volume Minimum0.030.03
Voltage Range110 VAC230 VAC
Weight Range Maximum5050
Weight Range Minimum11
Width English3.93.9
Width Metric1010
AC Adapter Weight English0.7 lb0.7 lb
AC Adapter Weight Metric0.3 kg0.3 kg
Depth English7.9 in7.9 in
Depth Metric20 cm20 cm
Height English3.1 in3.1 in
Height Metric8 cm8 cm
I E Ratio1:11:1
I E Ratio UOM%%
Net Weight English2.2 lb2.2 lb
Net Weight Metric1 kg1 kg
Respiration Rate Maximum400 breaths/min400 breaths/min
Respiration Rate Minimum60 breaths/min60 breaths/min
Tidal Volume Maximum0.13 ml/stroke0.13 ml/stroke
Tidal Volume Minimum0.03 ml/stroke0.03 ml/stroke
Weight Range Maximum50 g50 g
Weight Range Minimum1 g1 g
Width English3.9 in3.9 in
Width Metric10 cm10 cm

Journal Articles

Optimization of isolated perfused/ventilated mouse lung to study hypoxic pulmonary vasoconstrictionHae Young Yoo,1 Amy Zeifman,1 Eun A. Ko,1 Kimberly A. Smith,1 Jiwang Chen,1 Roberto F. Machado,1,2 You-Yang Zhao,3 Richard D. Minshall,3,5,6 and Jason X.-J. Yuan1,4Hypoxic pulmonary vasoconstriction (HPV) is a compensatory physiological mechanism in the lung that optimizes the matching of ventilation to perfusion and thereby maximizes gas exc
Activation of calpains mediates early lung neutrophilic inflammation in ventilator-induced lung injuryDejie Liu , Zhibo Yan , Richard D. Minshall , David E. Schwartz , Yuguo Chen , Guochang HuLung inflammatory responses in the absence of infection are considered to be one of primary mechanisms of ventilator-induced lung injury. Here, we determined the role of calpain in
Effect of permanent middle cerebral artery occlusion on Cytoglobin expression in the mouse brainZindy Raidaa, , , Riin Reimetsb, c, Anders Hay-Schmidta, Christian Ansgar Hundahla,Cytoglobin, a new member of the mammalian heme-globin family has been shown to bind oxygen and to have cell protective properties in vitro. Cytoglobin is specifically expressed in
Negative Hemodynamic Effects of Pantoprazole at High Infusion Rates in MiceBernhard Unsöld1,2,*, Nils Teucher3, Michael Didié1,4, Samuel Sossalla1, Claudius Jacobshagen1, Tim Seidler1, Wolfgang Schillinger1 andGerd Hasenfuß1Summary Background Pantoprazole has been shown to exert a negative inotropic effect in isolated myocardium. The purpose of this study was to evaluate the hemodynamic effects of pan
Protocol for the Induction of Subarachnoid Hemorrhage in Mice by Perforation of the Circle of Willis with an Endovascular FilamentDominik Bühler, Kathrin Schüller, Nikolaus PlesnilaGenetically engineered mice are a valuable tool to investigate the molecular and cellular mechanisms leading to brain damage following subarachnoid hemorrhage (SAH). Therefore, sev
Rapid Onset of Specific Diaphragm Weakness in a Healthy Murine Model of Ventilator-induced Diaphragmatic DysfunctionSegolene Mrozek, M.D., M.Sc.,* Boris Jung, M.D., Ph.D.,† Basil J. Petrof, M.D.,‡ Marion Pauly, M.Sc.,§ Stephanie Roberge, M.Sc.,§ Alain Lacampagne, Ph.D., Ce´ cile Cassan, Ph.D.,# Jerome Thireau, Ph.D.,** Nicolas Molinari, Ph.D.,†† Emmanuel Futier, M.D., M.Sc.,‡‡ Valerie Scheuermann, M.S.,§§ Jean Michel Constantin, M.D., Ph.D., Stefan Matecki, M.D., Ph.D.,## Samir Jaber, M.D., Ph.D.***Background: Controlled mechanical ventilation is associated with ventilator-induced diaphragmatic dysfunction, which impedes weaning from mechanical ventilation. To design future c
Brain function in iNOS knock out or iNOS inhibited (l-NIL) mice under endotoxic shockHanna Schweighöfer1 , Christoph Rummel2 , Konstantin Mayer3 and Bernhard Rosengarten1*Background: Microcirculatory dysfunction due to excessive nitric oxide productionby the inducible nitric oxide synthase (iNOS) is often seen as a motor of sepsis-related organ dysf